Extended Data Fig. 7: Complement activation and prognostic significance of C3aR expression in UPS patients. | Nature Cancer

Extended Data Fig. 7: Complement activation and prognostic significance of C3aR expression in UPS patients.

From: Complement activation promoted by the lectin pathway mediates C3aR-dependent sarcoma progression and immunosuppression

Extended Data Fig. 7

a-d, Representative magnification images (20X) of immunostaining analysis for C1q (a), C4d (b), C3c (c) and C3aR (d) in UPS tissue sections. One experiment performed (n = 19 patients), 10 representative fields have been acquired for each patient. Representative images for patients showing negative (0% IRA, left panel) or positive (>0% IRA, central and right panels) staining for C3aR expression (d). Scale bar: 100 µm. e–f, Kaplan-Meier survival curves representing the DFS (e) and the metastasis-free survival (f) for patients showing negative (n = 5 patients) or positive (n = 14 patients) staining for C3aR expression. Exact p value of Log-rank test for survival curves, Hazard ratio (HR) and confidence intervals (CI) are indicated in the figures (e, f).

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