Extended Data Fig. 2: Low EZH2 Activity is Associated with Enrichment in IFN Signaling and dsRNA Sensory Machinery. | Nature Cancer

Extended Data Fig. 2: Low EZH2 Activity is Associated with Enrichment in IFN Signaling and dsRNA Sensory Machinery.

From: EZH2 inhibition activates a dsRNA–STING–interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer

Extended Data Fig. 2

(a) Genes representing IFN signaling (STAT1, IRF9), Th1 chemokines (CXCL10, CXCL11), and MHC Class I molecules (B2M, HLA-A) were shown to be enriched in PCa patients with low EZH2 activity. (b) Genes representing intracellular sensors of dsRNA (TLR3, MAVs, RIG-I, MDA5) were shown to be enriched in PCa patients with low EZH2 activity. (c) Genes from Canadas et al. (2018) described as ‘SPARCs’ regulated by STAT1 and EZH2 that house endogenous retroviral sequences important for inducing an innate immune response, were shown to be enriched in PCa patients with low EZH2 activity. Sample numbers used for TCGA (n = 408 samples), SU2C (n = 118 samples), Beltran Adenocarcinomas (n = 33 samples), and NCI Primary Adeno (n = 41 samples). All data was generated by using Pearson correlation coefficient analysis.

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