Extended Data Fig. 7: Putative outcomes of all possible base-base mismatches. | Nature Cancer

Extended Data Fig. 7: Putative outcomes of all possible base-base mismatches.

From: A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage

Extended Data Fig. 7

Outcomes from 12 possible base-base mismatches. The red and black strands represent lagging and leading strands, respectively. The arrowed strand is the nascent strand. The highlighted pathways are the ones that generate C>A (blue), C>T (red) and T>C mutations (green) in the ∆MSH2 mutational signature.

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