Extended Data Fig. 3: Survival of leukemic mice after treatment. | Nature Cancer

Extended Data Fig. 3: Survival of leukemic mice after treatment.

From: Hotspot DNMT3A mutations in clonal hematopoiesis and acute myeloid leukemia sensitize cells to azacytidine via viral mimicry response

Extended Data Fig. 3

a, Representative FACS profiles of leukemia in spleen from +/+:myc-bcl2 and +/m: myc-bcl2 mice. Data are representative for n = 9 mice. b, Hematoxylin and eosin (H&E)–stained spleen and liver from +/+, +/+: myc-bcl2 and +/m: myc-bcl2, +/+:FLT3-ITD and +/m:FLT3-ITD mice. Histologically, leukemic splenic tissue has a markedly distorted organization compared to tissue from healthy C57BL/6N mice (+/+), which’h has organized areas of white pulp (WP) and red pulp (RP). (b, top) staining of spleen (original magnification of 5x), and (b, bottom) staining of liver (original magnification of x10). n = 3 mice for each genotype. c, Representative FACS profiles of leukemia in peripheral blood of +/+:FLT3-ITD (n = 5) and +/m:FLT3-ITD (n = 11) mice.

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