Extended Data Fig. 8: Single cell RNA sequencing clustering analysis. | Nature Cancer

Extended Data Fig. 8: Single cell RNA sequencing clustering analysis.

From: Chemotherapy induces canalization of cell state in childhood B-cell precursor acute lymphoblastic leukemia

Extended Data Fig. 8

a, UMAP clustering of the single cell RNA-seq xenograft data. The dimensionality reduction tool identifies 4 main clusters of cells. Clusters 0, 2 and 3 correspond to different states of untreated cells, while cluster 1 mostly comprises chemotherapy-treated cells. b, Heatmap showing the top positively differentially expressed features that characterize each of the UMAP clusters. c, UMAP plots visualizing the expression of selected biomarkers for each of the clusters. Images produced using the Seurat analysis package72.

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