Extended Data Fig. 1: Single cell whole genome sequencing analysis. | Nature Cancer

Extended Data Fig. 1: Single cell whole genome sequencing analysis.

From: Chemotherapy induces canalization of cell state in childhood B-cell precursor acute lymphoblastic leukemia

Extended Data Fig. 1

a, Representative traces of two whole-genome sequenced cells. Mapped reads are plotted across all chromosomes to highlight variations in copy number status as changes in the ploidy of the cells (n = 2). b, Diagram explaining the data processing pipeline. c, Scatterplots comparing the average normalized, GC-corrected and ploidy-adjusted counts per bins for pairs of copy-number events, where each dot represents an individual cell (n = 420 cells) harvested from Pt1 PDXs (across all treatment conditions and timepoints). Red lines divide the plots in 4 quadrants based on the nominal thresholds for calling each CNA.

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