Extended Data Fig. 4: Inhibition of PUS7 suppresses tumor progression.
From: Targeting PUS7 suppresses tRNA pseudouridylation and glioblastoma tumorigenesis
(a) Bioluminescent images of brain tumors in NSG mice transplanted with PBT003 GSCs that were transduced with control sgRNA (Control-sg) or PUS7 sgRNA (PUS7-sg). (b) Quantification of the bioluminescence intensity of tumors after PBT003 GSC transplantation. n = 5 mice for each group. Error bars represent SE of the mean. *p < 0.05 (p = 0.037) by one-tailed Student’s t-test. (c) The survival curves of NSG mice transplanted with PBT003 GSCs transduced with control sgRNA or PUS7 sgRNA. n = 5 mice for each group. The X axis represents days after GSC transplantation. Log-rank test for mice survival.
