Extended Data Fig. 10: Data supporting proof-of-concept disruption of CIP2A-TOPBP1 interaction. | Nature Cancer

Extended Data Fig. 10: Data supporting proof-of-concept disruption of CIP2A-TOPBP1 interaction.

From: The CIP2A–TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer

Extended Data Fig. 10

a, Determination of the EC50 growth inhibitory concentration of AS1 in DLD1 BRCA2-/- cells transduced with lentivirus expressing either the DD domain alone (EV) or B6L. Data is presented as the mean ± SEM. n = 3 technical replicates; analyzed with extra sum-of-squares F test. ***p = 1 × 10−15. b, Pharmacokinetic analysis of AS1 free plasma concentration over a 24 h period in mice. Data is presented as the mean of values from n = 3 animals. c, Analysis of cell viability by CellTiter GLo of the indicated DLD1 cell lines following celastrol (left) or TD-52 (right) treatments at the indicated concentrations. Data presented as the mean values ± S.D. n = 3 independent drug sensitivity assays; analyzed with extra sum-of-squares F test. Statistical analyses are found in Source Data ED Fig. 10.

Source data

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