Extended Data Fig. 1: Public version of the Molecular Tumor Board Portal.

a, The public MTBP is an open resource for research purposes that provides a lightweight version of the MTBP analytical pipeline. This public resource is accessed via a website (https://www.mtbp.org/) that offers an interface to upload the gene variants to analyze. At the moment of writing this manuscript, the public MTBP only supports the analysis of single-nucleotide variants and small indels. b, The public version of the MTBP does not issue actionability flags that require information that cannot be inferred from the generic input employed here and/or require interpretation nuances that may differ across investigators/institutions (such as matching with a given portfolio of clinical trials or the identification of germline incidental findings). Instead, the public MTBP provides a general interpretation of the functional and predictive relevance of the uploaded variants, with the aim of supporting a detailed review of the user according to his/her specific needs. c, Public MTBP website activity from the date of its release until the moment of writing this manuscript.