Extended Data Fig. 8: Identifying DNMT3A as a downstream target of KMT2C in SCLC. | Nature Cancer

Extended Data Fig. 8: Identifying DNMT3A as a downstream target of KMT2C in SCLC.

From: KMT2C deficiency promotes small cell lung cancer metastasis through DNMT3A-mediated epigenetic reprogramming

Extended Data Fig. 8

(a) The Venn diagram showing overlapping of the down-regulated genes in RNA expression, chromatin accessibility, H3K4me1 in PRM-Met compared to PRM. p-value was calculated by a hypergeometric test. (b) The scatter plot showing the correlation between the relative expression levels of KMT2C and DNMT3A in multiple SCLC cohorts. (c) The Kaplan-Meier survival curves of SCLC patients with high or low expressions of DNMT3A. (n = 55, low; n = 22, high).

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