Fig. 5: Characterization of possible drivers in patients with T-ALL.
From: Acute lymphoblastic leukemia displays a distinct highly methylated genome
a, Oncoprint showing genes with mutations in at least two T-ALL samples ordered by frequency. Mutation types are stratified. Bottom row indicates fusion genes per sample, if present. b, Hierarchical clustering using Ward’s distance based on the 500 most variable expressed genes across patients with T-ALL (n = 27 patients). Samples mainly group by genetic/transcriptomic subtype (such as TLX3). The methylation-based subtypes cannot be fully recapitulated, although RNA-based cluster 3 shows a tendency for higher methylated samples (not significant, P = 0.38, two-sided Fisher’s exact test).
