Extended Data Fig. 8: Cis-regulatory element accessibility of proapoptotic genes in late dysfunctional ccRCC infiltrating CD8+ T cells.
From: A single-cell map of dynamic chromatin landscapes of immune cells in renal cell carcinoma
a, Genome tracks of aggregate scATAC-seq data visualization of NFκB transcriptional targets gene loci, clustered as indicated in Fig. 1b. b, Violin plots of gene activity scores (left) and genome tracks of aggregate scATAC-seq data visualization of the NFκB transcriptional target genes (right), clustered as indicated in Fig. 1b. Pair-wise comparisons of gene activity scores for the indicated gene between specified T cell clusters were determined using a two-sided Wilcoxon rank-sum test. Resulted p values further underwent multi-test correction with the FDR method (**, adjusted-p < 0.01; ****, adjusted-p < 0.0001; raw adjusted p values are listed in the Source Data file; for clusters 4, 5, 7, 8, 9, 10, 11, n = 1810, 1821, 873, 924, 1775, 2440 and 1613 cells, respectively). c, Genome tracks of aggregate scATAC-seq data visualization of proapoptotic gene loci, clustered as indicated in Fig. 1b.
