Extended Data Fig. 3: TF motif enrichment in open chromatin regions of T cells in ccRCC.
From: A single-cell map of dynamic chromatin landscapes of immune cells in renal cell carcinoma
a, UMAP projection of T cell scATAC-seq profiles colored by chromVAR TF motif bias-corrected deviations for the indicated TFs (two-sided Wilcoxon rank sum test; p < 2.2×10−16 for the TFs in the indicated clusters -CD4 clusters: LEF1, TCF7, FOXO1, TCF7, STAT1, BACH2 and CD8 clusters: RREB1, KLF3, TWIST2- compared to the other CD4 or CD8 T cell clusters, respectively). b, UMAP projection of T cell scATAC-seq profiles colored by chromVAR TF motif bias-corrected deviations for the indicated TFs (two-sided Wilcoxon rank sum test; p < 2.2×10−16 for STAT3 and STAT5 in C4_CD8 compared to the other CD8 T cell clusters, p < 2.2×10−16 for POU2F1 in C12_CD4 compared to the other CD4 T cell clusters). c, UMAP projection of T cell scATAC-seq profiles colored by chromVAR TF motif bias-corrected deviations for the indicated TFs (two-sided Wilcoxon rank sum test; for TBX5, p < 2.2×10−16 for C11_CD8 compared to C10_CD8 or C9_CD8, p < 2.2×10−16 for C9,10,11_CD8 compared to the other clusters; for IRF1, NFATC2, NFATC3, and EPAS1, p < 2.2×10−16 for the indicated cluster compared to the other clusters; a, b, c, n = 18736 cells).
