Extended Data Fig. 9: Subtype-specific RMS core signatures are expressed at specific muscle development stages. | Nature Cancer

Extended Data Fig. 9: Subtype-specific RMS core signatures are expressed at specific muscle development stages.

From: Single-cell analysis and functional characterization uncover the stem cell hierarchies and developmental origins of rhabdomyosarcoma

Extended Data Fig. 9

a,b Dot plot renderings showing the expression of ten representative genes that comprise the fusion-negative or fusion-positive core signature across all PDXs and their identified cell states (a) and across normal muscle cells stratified by age (b). c UMAP rendering of scRNA sequencing data from embryonic (n = 5 samples), fetal (n = 4 samples), and adult skeletal muscle (n = 4 samples) showing expression of representative subtype-specific core signature genes. Week or year of life is noted (Wk and Yr, respectively). n = 3,251 cells analyzed across all stages of muscle development.

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