Extended Data Fig. 2: Identification of tumor-specific CD8 T cell clones.
a, Determination and classification of n = 31 tumor-specific and n = 57 bystander CD8 T cell clones by using CXCL13 expression and exhaustion score. Data were summarized from pre-treatment responsive BCC and SCC tumors; N = 15 patients. b, ROC curves for the performance of individual exhaustion-related genes and CXCL13 in discriminating tumor-specific from bystander CD8 T cell clones from post-treatment responsive tumors. The antigen specificities of post-treatment CD8 T cell clones were determined based on matched pre-treatment clones in a. The sample size is the same as in a. c, Determination and classification of n = 44 tumor-specific and n = 29 bystander CD8 T cell clones by using CXCL13 expression and exhaustion score. Data were summarized from pre-treatment responsive breast tumors; N = 4 patients. d, ROC curves for the performance of individual exhaustion-related genes and CXCL13 in discriminating tumor-specific from bystander CD8 T cell clones from post-treatment responsive tumors. The antigen specificities of post-treatment CD8 T cell clones were determined based on matched pre-treatment clones in c. The sample size is the same as in c.
