Extended Data Fig. 3: Isolation of CXCL13 + CD8 T cell clones and T cell expansion.
a, Density plots showing the distribution of CXCL13 and CD8A expression across all T cell clones. For each dataset, the threshold for identifying CXCL13- or CD8A-positive clones was determined as the inflection point of the density curve (the vertical line). Data were summarized from n = 20 (the Liu et al. data), 15 (the Caushi et al. data), 22 (BCC), 7 (SCC), 53 (breast cancer cohort 1), 22 (breast cancer cohort 2), 12 (breast cancer cohort 3), 7 (RCC; Krishna et al.) and 4 (RCC; Bi et al.) tumor samples. b, Comparison of the number of expanded CXCL13+ clonotypes (clonal size ≥ 2 and ≥ 20, respectively) between treatment responses. Samples analyzed here were the same as in a, presented as mean ± s.e.m. Two-sided Wilcoxon test.
