Extended Data Fig. 4: Molecular dissection of the immediate response to anti-CTLA-4 mAbs. | Nature Cancer

Extended Data Fig. 4: Molecular dissection of the immediate response to anti-CTLA-4 mAbs.

From: Anti-CTLA-4 antibodies drive myeloid activation and reprogram the tumor microenvironment through FcγR engagement and type I interferon signaling

Extended Data Fig. 4

(a) 12 leading DEGs for myeloid cell populations. Log2 fold-change is relative to all other cells. (b) Number of DEGs per metacluster in anti-CTLA-4 m1 vs. control. (c) Scatterplot comparing anti-CTLA-4 m2a (Y) vs. Control (X) gene expression changes in monocytes. Leading DEGs are annotated. (d) Scatterplot comparing anti-CTLA-4 m2a (Y) vs. Control (X) gene expression changes in TAMs. Leading DEGs are annotated. (e) Scatterplot comparing anti-CTLA-4 m2a (Y) vs. Control (X) gene expression changes in monocytes and TAMs combined. Leading DEGs are annotated. Differential gene expression is estimated using two-sided Wilcoxon rank-sum test, Benjamini-Hochberg adjusted p-value < 0.05, FC > 1.25.

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