Fig. 1: SLC4A4 is almost exclusively expressed in the epithelial compartment of PDAC tumors. | Nature Cancer

Fig. 1: SLC4A4 is almost exclusively expressed in the epithelial compartment of PDAC tumors.

From: Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer

Fig. 1

a, Uniform manifold approximation and projection (UMAP) map of color-coded cells for the indicated cell types isolated from treatment-naive individuals with PDAC (n = 10 individuals). b, Dot plot of normalized expression of different bicarbonate transporters in the indicated cell types. c, UMAPs showing the expression of EPCAM (marker of pan-epithelial cells), SLC4A4, SPP1 (marker of ductal cells) and SPINK1 (marker of acinar cells). d, Dot plot of normalized expression of SLC4A4 in the epithelial compartment of each individual. e, Violin plot from TCGA data representing SLC4A4 expression in PDAC or adjacent pancreatic tissue (n = 182 individuals). f,g, Representative images of IHC staining for SLC4A4 in PDAC (f) or adjacent pancreatic tissue sections (g); n = 7 individuals; scale bar, 1 mm. P value was assessed by unpaired, two-tailed Student’s t-test (e).

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