Extended Data Fig. 1: Relationship between ISGs and T cell activity in TCGA tumors. | Nature Cancer

Extended Data Fig. 1: Relationship between ISGs and T cell activity in TCGA tumors.

From: Cancer cells resistant to immune checkpoint blockade acquire interferon-associated epigenetic memory to sustain T cell dysfunction

Extended Data Fig. 1

A. Schematic depicting the datasets and strategy used for the integrated analysis of RNA-seq and ATAC-seq data from TCGA tumor samples. B. CD8 T cell cytolytic activity scores (CD8 cytolytic activity) for all TCGA tumors, ordered by increasing median score (red line) for each cancer type. Cancer types with grey labels were excluded from analysis due to known low immune infiltration or low numbers of samples with paired RNA and ATAC data. C. Standardized regression coefficient estimates representing the effect of modified Z-score normalized RNA expression of IFNG.GS, ISG.RS, or 250 random gene sets (n = 38, same size as ISG.RS gene set) on CD8 T cell cytolytic activity. D. Histogram of number of putative cis-regulatory elements linked to each ISG.RS gene.

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