Extended Data Fig. 2: OAS1 cis-regulatory elements in TCGA tumors. | Nature Cancer

Extended Data Fig. 2: OAS1 cis-regulatory elements in TCGA tumors.

From: Cancer cells resistant to immune checkpoint blockade acquire interferon-associated epigenetic memory to sustain T cell dysfunction

Extended Data Fig. 2

A-C. ATAC tracks at the OAS1 loci for representative LUAD, LUSC, and STAD tumors with high (blue) or low (red) CD8 T cell cytolytic activity. The annotation bar (bottom) demarcates called peaks, with black and grey bars indicating putative cis-REs linked to OAS1 and other peaks in the region, respectively. Highlighted peaks indicate putative cis-REs that negatively correlate with CD8 T cell cytolytic activity. The correlation of average OAS1 cis-RE chromatin accessibility with CD8 T cell cytolytic activity across all paired tumor samples available for each cancer type is depicted in Fig. 1i.

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