Extended Data Fig. 6: Association of SBS signatures with patient age and genomic features.
a) Correlation of age at diagnosis and SBS signature activity. Colors indicate different cancer types as in Fig. 1a (Spearman’s correlation, confidence interval 0.95. P value is indicated, n = 727 tumors) b) Association of TP53 mutation status and SBS2, SBS13 signature activities c) Number CC > TT dinucleotide substitutions in SBS7a/b positive B-ALL-HYPO tumors d) Association of SBS8 and chromothripsis e) Association of SBS18 and MYCN amplification in neuroblastoma b-e: boxplots show lower and upper quartile and median line is indicated. Range of whiskers: 1.5 x interquartile range (significance values are computed with two-sided Wilcoxon rank sum test, confidence interval 0.95. Wherever appropriate, p-values are adjusted for multiple testing with Benjamini-Hochberg method). The ‘n’ in b-e represents the number of tumors f) Association of SBS40 with genomic instability. Colors are same as SBS signature color coding as in Extended Data Fig. 4, 5 (Spearman’s and Pearson’s correlation, confidence interval 0.95, n = 75 tumors) g-i) Transcriptional strand asymmetries of SBS5, SBS7a, SBS31 and SBS35 (Fischer exact test, p.values are adjusted for multiple testing with Benjamini-Hochberg method) j) Replication strand asymmetries of SBS5, SBS15, SBS44 (Fischer exact test, p.values are adjusted for multiple testing with Benjamini-Hochberg method). The ‘n’ in figures g-j indicates the number of tumors used for analysis.
