Extended Data Fig. 3: Brain metastatic burden and survival in mice injected with breast cancer cells. | Nature Cancer

Extended Data Fig. 3: Brain metastatic burden and survival in mice injected with breast cancer cells.

From: Reciprocal interactions between innate immune cells and astrocytes facilitate neuroinflammation and brain metastasis via lipocalin-2

Extended Data Fig. 3

a. Experimental scheme analyzed in (b,c). b. Survival curve analysis of WT and Lcn2-/- mice injected intracardially with BT-EO771 cells, (WT n = 10, Lcn2-/- n = 9 mice) (Kaplan–Meier curve, log-rank test). c. Quantification of brain metastatic burden for mice in (a), quantified as % CD45- mCherry+ tumor cells/live cells, (ctrl n = 9, WT n = 9, Lcn2-/- n = 7 mice) (one-way ANOVA). d. Gating strategy for isolation by FACS of different cells populations from WT and Lcn2-/- BrM mice injected intracardially with BT-RMS or BT-EO771 cells 18 days after injection.

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