Extended Data Fig. 7: LCN2 is highly expressed in granulocytes in human BrM and can help direct patient’s care in combination with clinically used prognostic factors. | Nature Cancer

Extended Data Fig. 7: LCN2 is highly expressed in granulocytes in human BrM and can help direct patient’s care in combination with clinically used prognostic factors.

From: Reciprocal interactions between innate immune cells and astrocytes facilitate neuroinflammation and brain metastasis via lipocalin-2

Extended Data Fig. 7

a. Immunofluorescence staining in frozen sections of resected human brain metastases from melanoma, breast and lung primary origin. Co-localization of LCN2 with CD66b (granulocytes). Representative images of separate staining are shown from n = 2 patients samples stained per cancer type. b. Five-year survival curve analysis of patients with low versus high LCN2 levels in patients with lung cancer BrM. The cutoff between high and low levels was defined as the median LCN2 level (Kaplan–Meier curve, log-rank test). c. Five-year survival curve analysis of patients with KPS score over or under 70, in patients with lung cancer BrM. d. 5-year survival curve analysis of patients with KPS score < 70, stratified to low versus high LCN2 levels in patients from Fig. 7h.

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