Extended Data Fig. 2: YC-1 sensitivity does not correlate to known mechanisms of action.
From: SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers
a, A panel of cancer cell lines, including IDHm and IDH WT ICC cells lines used in the initial chemical screens (shaded columns), were profiled for sensitivity to known HIF1α inhibitors and sGC agonists with highest dose of ~40 μM covering the effective range. Square size denotes sensitivity (AUC) of each cell line to a given compound, square color denotes the efficacy of the compound. b, Scatter plot of normalized CRISPR dependency scores (DepMap) of HIF1A, HIF2A (EPAS1) and VHL (as control) in hepatobiliary cell lines.
