Extended Data Fig. 6: Distribution of immune cells across different tumor grades for mIHC cohort.
(a)Table listing p values for correlation of individual immune cell subsets like CD4, CD8 T cells, total macrophages and M1-like and M2-like macrophage with distribution across grade within IDC and ILC. Grade1 (IDC n = 3, ILC n = 3 patients), grade 2 (IDC n = 30, ILC n = 29 patients), grade 3 (IDC n = 16, ILC n = 3 patients). Two-sided Kruskal Wallis test was used for statistical analysis with p < 0.05 considered significant. (b) Correlation of immune cell frequencies in the tumor compartment with pathological grade in all biologically independent ER+ patient samples and across grades 1,2 and 3 in ER+ IDC vs ILC. Center of the box plot represents median with 25th and 75th percentile bounds of the box and whiskers representing least and highest value in dataset. Two-sided Kruskal- Wallis test was used for statistical analysis with p < 0.05 considered significant.(c) Correlation of immune cell frequencies in the stromal compartment with pathological grade in all biologically independent ER+ patient samples and across grades 1,2 and 3 in ER+ IDC vs ILC. Center of the box plot represents median with 25th and 75th percentile bounds of the box and whiskers representing least and highest value in dataset. Kruskal- Wallis test was used for statistical analysis with p < 0.05 considered significant.
