Extended Data Fig. 9: scRNAseq cluster characteristics. | Nature Cancer

Extended Data Fig. 9: scRNAseq cluster characteristics.

From: Immune landscape in invasive ductal and lobular breast cancer reveals a divergent macrophage-driven microenvironment

Extended Data Fig. 9

(a) Density UMAP representing differential cell densities in ER+ TIL (n = 14 samples, top panel) and ER+ PBL (n = 15 samples, bottom panel) (b) Inter patient heterogeneity in percent contribution of immune cell subsets in ER+ IDC and ILC TIL (n = 14, top panel) and ER+ IDC and ILC PBL (n = 15, bottom panel). Percent contributions for cell subsets normalized to total number of cells recovered from each patient. (c) Density UMAP representing differential cell densities in ER+ IDC (middle panel) vs ER+ ILC (right panel) with original tumor infiltrating macrophages UMAP projection as reference (left panel). (d) Table listing top 20 significant genes driving the latent time trajectory of tumor infiltrating macrophages in their respective clusters.

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