Extended Data Fig. 5: Genomic evolution of metastatic disease. | Nature Cancer

Extended Data Fig. 5: Genomic evolution of metastatic disease.

From: Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancer

Extended Data Fig. 5

a) Phylogenetic sample trees of Cluster#1 (top left) and Cluster#2 (bottom left) RCC tumor-bearing mice; different pattern of evolution can be clearly appreciated. Oncoprints of Cluster#1 (top right) and Cluster#2 (bottom right) RCC tumor-bearing mice displaying time of driver engineered and spontaneous somatic events in primary and secondary lesions.

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