Fig. 5: CIN is associated with interferon signaling suppression in RCC.
a, Dot plot showing copy number log values of the IFNAR2 gene across human cell lines derived from nonhematological malignancies as calculated from the Cancer Cell Line Encyclopedia (CCLE). Cell lines were divided based on their aneuploidy score; P = 0.0099. b, Dot plot showing copy number log values of the IL10RB gene, across the same cell lines as a. P = 0.0099, n = 789 cell lines. c, Dot plot showing copy number log values of the IFNAR1 gene, across the same cell lines as a. P = 0.00992, n = 789 cell lines. d, Dot plot showing copy number log values of the IFNGR2 gene, across the same cell lines as a. P = 0.015, n = 789 cell lines. e, Scatter dot plot copy number log values of two IFNR genes located on the specific deleted chromosome 21 region; P < 1 × 10−15. n = 789 cell lines. f, Heatmap displaying the clinical, histological and genomic annotation of specific features across MSKCC RCC cohort (upper left panel), TRACERx RCC cohort (bottom left panel) and TCGA-KIPAN cohort (upper right panel). g, Bar plot showing co-occurrence of 21q loss and 9p loss in the three different clinical cohorts; from left to right, P = 1.04 × 10−4 and 0.0016. From left to right, n = 788, 101 and 134 tumors. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001 by two-sided Mann–Whitney test (a–d), Pearson correlation (e) and two-sided Fisher exact chi-squared test (g). N/A, not applicable; WT, wild type.
