Extended Data Fig. 1: Clinical features of RCC characterized by loss of 9p. | Nature Cancer

Extended Data Fig. 1: Clinical features of RCC characterized by loss of 9p.

From: Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancer

Extended Data Fig. 1

a) Odds plot showing enrichment fatal events in NF2KO/9p− cases and stage III/IV among MSKCC cohort patients, data are represented as hazard ratios with upper and lower limits (N = 134 patients), p values = 2.70*10-4 and 1.68*10-7. b-c) Bar charts showing the prevalence of metastasic (b), p value = 9.21*10-3, and sarcomatoid (c), p value = 1.80*10-4 features in NF2wt/9pwt, NF2KO/9pwt, NF2wt/9p−, and NF2KO/9p- cases in the MSKCC cohort (N = 52, 10, 51, and 21 patients, respectively). d) Representative H&E stained images from two MSKCC cohort cases. Upper panel: NF2KO/9pwt; bottom panel: NF2KO/9p-. Images representative of the genomic background. In the latter, sarcomatoid features are readily observed. e) Kaplan–Meier survival analysis of human RCCs with and without sarcomatoid features in MSKCC (N = 16 vs N = 97 patients) (left panel), TCGA (N = 45 vs N = 743 patients) (middle panel) and TRACERx (N = 10 vs N = 91 patients) (right panel) cohorts, p values = 2.37*10-4, p value < 1*10-15 and p value = 0.016. f) Kaplan–Meier survival analysis of human RCCs with and without 9p loss features in MSKCC (N = 72 vs N = 62 patients) (left panel), TCGA (N = 140 vs N = 658 patients) (middle panel) and TRACERx (N = 57 vs N = 38 patients) (right panel) cohort, p values = 0.023, 1.21*10-8, 0.045. g-h) Bar chart showing the prevalence of sarcomatoid features in 9pwt and 9p- cases in TCGA pan-RCC dataset (N = 648 vs N = 140 tumors) (g), p value = 0.025, and TRACERx RCC dataset (N = 45 vs N = 61 tumors) (h). i-j) Bar chart showing the prevalence of stage I/II and stage III/IV features in 9pwt and 9p- cases in TCGA pan-RCC dataset (N = 628 vs N = 136 patients) (i) and TRACERx RCC dataset (N = 45 vs N = 61 patients) (j), p values = 1.56*10-8 and 9.29*10-5. k-l) Bar chart showing the prevalence of metastasis features in 9pwt and 9p- cases in TCGA pan-RCC dataset (N = 628 vs N = 136 patients) (k) and TRACERx RCC dataset (N = 45 vs N = 61 patients) (l), p values = 2.86*10-4 and 0.008. ns.: not significant, * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001 by two-sided Fisher’s exact test (b, c, g-l), log-rank (Mantel–Cox) test (a,e, f). Scale bar: 100 μm.

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