Extended Data Fig. 3: U5 snRNP200 expression in normal murine hematopoietic cells. | Nature Cancer

Extended Data Fig. 3: U5 snRNP200 expression in normal murine hematopoietic cells.

From: Systematic evaluation of AML-associated antigens identifies anti-U5 SNRNP200 therapeutic antibodies for the treatment of acute myeloid leukemia

Extended Data Fig. 3

(a) Median fluorescence intensity (MFI) values of U5 snRNP200 expression on immune cell populations from six normal adult bone marrow samples (n = 6 donors). Bar graphs represent mean ± SEM. (b) Quantification of U5 snRNP200 expression across immune cell subsets in the spleen and bone marrow (n = 5 mice). Bar graphs represent mean ± SEM. (c) Representative histogram (left panel) and quantification of U5 snRNP200 expression on peripheral blood immune cell subsets. n = 5 mice. Bar graphs represent mean ± SEM. (d) Representative histogram (left panel) and quantification of U5 snRNP200 expression on bone marrow stem cells compared to B-cells. n = 5 mice. Bar graphs represent mean ± SEM. (e) Quantification of U5 snRNP200 expression across B cell differentiation states. n = 5 mice. Bar graphs represent mean ± SEM. MFI = mean fluorescent intensity. (f) Histogram of U5 snRNP200 cell surface expression on K562 cells versus normal non-hematopoietic tissues stained for U5 snRNP200 versus unstained K562 cells.

Source data

Back to article page