Extended Data Fig. 5: Changes in cellular population across time and response. | Nature Cancer

Extended Data Fig. 5: Changes in cellular population across time and response.

From: Genomic and immune signatures predict clinical outcome in newly diagnosed multiple myeloma treated with immunotherapy regimens

Extended Data Fig. 5

Boxplot showing the differences in cellular populations between T1 (baseline) and T2 (post-therapy) in patients that achieve or fail to achieve sustained MRD-negativity. N1=sustained MRD-negativity group at T1 (n = 9), N2=sustained MRD-negativity group at T2 (n = 10), P1=no sustained MRD-negativity group at T1 (n = 8), P2=no sustained MRD-negativity group at T2 (n = 10). Two-sided p-values were estimated using Kruskal-Wallis test. Boxplots represent quartiles centered around the median. a. Memory B-cells b. Naïve B-cells. c. B1 Progenitor cells d. B2 progenitor cells e. Dendritic cell Progenitor. f. megakaryocytic progenitor g. lympho-myeloid progenitor. h. red blood cell progenitor, i. granulocyte-monocyte progenitor j. hematopoietic stem-cell. k. gamma/delta T-cell l. mucosae-associated T-cells m. Regulatory T-cells, n. CD4 effector 1, o. CD4 effector 2, p. CD8 memory 1, q. CD8 memory 2, r. CD8 naïve, s. CD4 memory. t. CD4 naïve u CD4/CD8 ratio, v. classical dendritic cells 2, w. Plasmacytoid dendritic cells.

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