Extended Data Fig. 7: Transcriptomic analysis of gastric cancer EPO-GEMMs.
From: Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease
(a, b) Venn diagrams showing overlap of differentially upregulated (A) or down regulated (B) genes (vs. healthy stomach) for the indicated EPO-GEMM tumor genotypes. Key pathways enriched in each gene subset are labeled accordingly. Complete lists of pathway predictions are provided in Supplementary Tables 6–19. (c–e) Complete lists of the Hallmark Pathways and NES scores shown in Fig. 4b, along with the NES scores for human gastric tumors of the corresponding subtypes. (f) Gene set enrichment analysis (GSEA) for Hallmark p53 Pathway comparing MYC-p53−/− and MYC-Apc−/− gastric tumors. (g) Comparison of GSEA NES scores for hallmark pathways (left) or immune populations (right) enriched in mouse (y axis) and human (x axis) MSI gastric tumors. Highlighted are key immune populations enriched in MSI tumors. Circle size represents -log(adjusted P value). A complete list of NES scores is provided in Supplementary Tables 20, 21.
