Extended Data Fig. 6: Sirpα deficiency reprogramed macrophage subsets and lineage in tumor. | Nature Cancer

Extended Data Fig. 6: Sirpα deficiency reprogramed macrophage subsets and lineage in tumor.

From: Sirpα on tumor-associated myeloid cells restrains antitumor immunity in colorectal cancer independent of its interaction with CD47

Extended Data Fig. 6

a. Expression level of the top 3 subset-specific genes of each subset in all myeloid cell subsets. b. The top significantly enriched signatures of cluster mMDSC1-2 and TAM1-4. c. Smoothed gene expression trends of the top 100 genes whose expression values correlate best with lineage 1 (to TAM3) fate probabilities, sorted according to peak in pseudotime. Not all gene names are shown. d. Smoothed expression trends in pseudotime for the lineage 1 (to TAM3) related genes Dnase1l3, Cd81, S100a10 and Tmsb10 (95% CI). e. Expression of upregulated genes (top) and down-regulated genes (bottom) in TAM3 compared to TAM2. All genes show significantly statistic differences between TAM3 and TAM2 subsets (Wilcoxon test, two-sided, p < 0.05).

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