Extended Data Fig. 1: Myeloid cells demonstrate pro-tumor signatures in tumor tissues of colorectal cancer patient. | Nature Cancer

Extended Data Fig. 1: Myeloid cells demonstrate pro-tumor signatures in tumor tissues of colorectal cancer patient.

From: Sirpα on tumor-associated myeloid cells restrains antitumor immunity in colorectal cancer independent of its interaction with CD47

Extended Data Fig. 1

a. t-SNE visualization of cell type specific genes colored by expression level. b. Cell proportion of each cell type in CRCN, CRCP and CRCT tissues calculated by scDC. The p value were calculated by bootstrap resampling through GLM model in scDC. c. Heat map of top 3 differentially expressed genes in each myeloid cell cluster. Color represents scaled gene average expression in each cluster. d, e. Volcano plot of differentially expressed genes in macrophage (d) and neutrophil (e) between tumor tissue and normal/paracancerous tissue (Wilcoxon test, two-sided). Red points and blue points represent tumor tissue highly expressed genes and normal/paracancerous tissue highly expressed genes, respectively. Bonferroni was used for correction of multiple comparisons.

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