Extended Data Fig. 2: Tumor enriched myeloid cells exhibits the highest immune-inhibitory signatures in big data. | Nature Cancer

Extended Data Fig. 2: Tumor enriched myeloid cells exhibits the highest immune-inhibitory signatures in big data.

From: Sirpα on tumor-associated myeloid cells restrains antitumor immunity in colorectal cancer independent of its interaction with CD47

Extended Data Fig. 2

a–c. UMAP projection of 455,959 immune cells in 131 CRC patients from syn26844071, GSE188711 and GSE178341, colored by cell type (a), tissue (b) and TNM stage (c). d. Immune-inhibitory scores of each cell type in tumor tissues. e. The significantly enriched signatures of TAM specific genes. Color depth represents -Log10 (p value). f-k. The expression of immune-inhibitory genes on macrophages (f) and neutrophils (g) from all the 131 CRC patients, as well as macrophages from stage I (h), stage II (i), stage III (j), and stage IV (k), between tumor and normal tissues (Wilcoxon test, two-sided).

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