Extended Data Fig. 5: Malat1 regulated 4T1 metastasis is antithetically controlled by CD8 T cells and neutrophils.
From: LncRNA Malat1 suppresses pyroptosis and T cell-mediated killing of incipient metastatic cells
a, Feature Plot of activation, lytic immune, immune suppressor, and antigen presentation function genes at indicated conditions. b, UMAP of neutrophils isolated from the lungs of mice inoculated 4 weeks earlier with 4T1 cells identifies seven clusters. c, DittoPlots of neutrophil maturation markers, immunosuppressive markers, and gelatinase granules. d, UMAPs represent scRNA-seq analyses of CD45+ cells from 4T1 primary tumors. e, Comparison of immune cells infiltration during the development of spontaneous lung metastases in mice injected with Dox-inducible control or Malat1-targeting mirE shRNAs.
