Extended Data Fig. 9: SERPINB6 is associated with poor prognosis in breast cancer.
From: LncRNA Malat1 suppresses pyroptosis and T cell-mediated killing of incipient metastatic cells
a, Expression of SERPINB6 in normal (N) and invasive breast cancer (IBC) samples (source Finak breast dataset, Oncomine). b, Expression of SERPINB1, B6, and B9 in breast cancer samples (source http://gepia2.cancer-pku.cn/#analysis). Box plots for fig a and b span the first to third quartiles and whiskers show 1.5 × interquartile range. c, Heatmap shows the level of expression of Serpins genes from differentially expressed in control versus Malat1 KO MMTV-neu cells. Highlighted Serpin genes are the common downregulated Serpins family from DEGs list upon Malat1 KO in MMTV-neu and 4T1 cells. d, KM plotter analysis of Overall Survival (OS) based on expression level of SERPINA3, SERPINB1, and SERPINB6 from RNA-seq data of breast cancer patients. e and f, Overall Survival correlation of indicated Serpins from Liu_2014 and Tang_2018 proteomic datasets68. P values in a and b were calculated using a two-tailed, unpaired Student’s t-test.
