Fig. 4: Biological relevance of top features in muti-omic model and clustering.
a, Spearman correlation of top multi-omic features with DS. Size represents a feature’s relative importance to the top multi-omic model; the red color indicates whether the feature importance pertains to DS. b, Gene Ontology network visualization for most informative features from the multi-omic models. Selected functional pathways containing gene sets from multi-omic analytes are displayed as green nodes, with associated genes and measured analyte types represented by a specific shape (based on analyte) and colored according to the strength of a given analyte’s correlation to the outcome variable of DS. Size of a given analyte node is relative to the frequency with which that analyte was selected for the models, with larger analytes more consistently selected and no visible node indicating that the analyte was not selected as important for the DS outcome displayed. c, UMAP clusters of patients using molecular signatures consisting of all 6,363 multi-omic features, colored by survival.
