Table 1 Top single-omic and multi-omic analytes for predicting disease survival in PDAC in the MT-Pilot cohort
Analytes | No. of samples | No. of features | TP | FP | TN | FN | ACC (95% CI) | PPV (95% CI) | Sensitivity | Specificity |
|---|---|---|---|---|---|---|---|---|---|---|
Multi-omic | 39 | 6,363 | 26 | 4 | 7 | 2 | 0.85 (0.73–0.96) | 0.87 (0.75–0.99) | 0.93 | 0.64 |
Plasma proteins | 51 | 257 | 32 | 8 | 6 | 5 | 0.75 (0.63–0.86) | 0.80 (0.68–0.92) | 0.86 | 0.43 |
RNA fusions | 57 | 29 | 35 | 12 | 8 | 2 | 0.75 (0.64–0.87) | 0.74 (0.62–0.87) | 0.95 | 0.40 |
Tissue proteins | 49 | 1,130 | 32 | 10 | 4 | 3 | 0.73 (0.61–0.86) | 0.76 (0.63–0.89) | 0.91 | 0.29 |
Plasma lipids | 51 | 406 | 34 | 12 | 2 | 3 | 0.71 (0.58–0.83) | 0.74 (0.61–0.87) | 0.92 | 0.14 |
Clinical and surgical pathology | 74 | 331 | 47 | 19 | 5 | 3 | 0.70 (0.60–0.81) | 0.71 (0.60–0.82) | 0.94 | 0.21 |
RNA gene expressions | 57 | 2,000 | 33 | 14 | 6 | 4 | 0.68 (0.56–0.80) | 0.70 (0.57–0.83) | 0.89 | 0.30 |
Computational pathology | 71 | 819 | 34 | 11 | 13 | 13 | 0.66 (0.55–0.77) | 0.76 (0.63–0.88) | 0.72 | 0.54 |
DNA CNVs | 72 | 648 | 43 | 20 | 4 | 5 | 0.65 (0.54–0.76) | 0.68 (0.57–0.80) | 0.90 | 0.17 |
DNA INDELs | 72 | 126 | 39 | 17 | 7 | 9 | 0.64 (0.53–0.75) | 0.70 (0.58–0.82) | 0.81 | 0.29 |
DNA SNVs | 72 | 611 | 45 | 23 | 1 | 3 | 0.64 (0.53–0.75) | 0.66 (0.55–0.77) | 0.94 | 0.04 |
CA 19-9 presurgery | 63 | 1 | 17 | 15 | 20 | 11 | 0.59 (0.47–0.71) | 0.53 (0.40–0.65) | 0.61 | 0.57 |
