Extended Data Fig. 6: CD4+T-cell phenotypes defined using scRNA-seq. | Nature Cancer

Extended Data Fig. 6: CD4+T-cell phenotypes defined using scRNA-seq.

From: Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling

Extended Data Fig. 6

(a) Comparisons of the T-cell migration scores between all CD4+ T cells (n = 12,527) from 9 CR and PD/PR IPs. The black bar represents the median and the dotted lines denote quartiles. P values were computed using two-tailed Welch’s T-test. (b) UMAP for CD4+ T cells (n = 12,527). Nine clusters were identified using unsupervised clustering. (c) Heat map of two CD4+ T-cell clusters generated by unsupervised clustering. CD4-4 mostly cells from PR/PD while CD4-1 are enriched with CR cells. A color-coded track on top shows the cells from infusion products of CR (green) and PR/PD (red). The track below the heatmap, shows the sample origin for each cell. (d) Bubble plot showing key genes differentially expressed among CD4+ T clusters. P value was calculated using the Wilcoxon rank sum test with Bonferroni correction.

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