Extended Data Fig. 8: Enrichment and functional characterization of migratory 19-28z T cells.
(a) Comparisons between the migration of migrated (migratory) and unsorted cells as measured by TIMING (1E:0T). The black bar represents the median and the dotted lines denote quartiles. P value was computed using two-tailed Welch’s t-test. (b) The frequency of conjugation of T cells to tumor cells comparing migratory and unsorted 19-28z T cells evaluated using TIMING (1E:1T). P value was computed using a two-tailed chi-square test. (c) Killing percentage of migratory and unsorted 19-28z T cells evaluated using TIMING (1E:1T). P value was computed using a two-tailed chi-square test. (d) Phenotyping of matched 19-28z and migratory 19-28z T-cell populations. This data is representative of at least four healthy donor-derived T-cell populations measured by flow cytometry. Gating strategies are shown from the side scatter and forward scatter panels on the far left.
