Extended Data Fig. 7: Differential protein levels in plasma cell leukemias indicate a highly proliferative phenotype.
a: Global protein or phosphopeptide levels in multiple myeloma samples (n = 114) were compared against MGUS (n = 7) or plasma cell leukemia (n = 17) samples with a 2-sided, moderated 2-sample t-test. P-values were adjusted with the Benjamini-Hochberg method. Significant (< 0.05 FDR) proteins or phosphopeptides in each comparison are plotted across their genomic location. b: Global protein levels in plasma cell leukemia samples isolated from blood (n = 12) or bone marrow (n = 5) were compared with a 2-sided, moderated 2-sample t-test. The log2 of fold change of each protein is plotted against its p-value. P-values were adjusted with the Benjamini-Hochberg method and the significance threshold of 0.05 FDR is indicated. Bottom plot shows the same analysis for phosphoproteomic data. c: Heatmap displays normalized levels of the most significantly regulated proteins between MM and PCL or MM and MGUS (by FDR).
