Extended Data Fig. 8: Univariate KM curves of time to metastasis for Gleason grading and Gleason Morisita.
From: Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer
(A) Gleason grading from original reporting pathologists (Imaging Cohort, n = 250 participants, two-sided log-rank test, χ2 = 7.05, d.f. = 3, P = 0.27). (B) Gleason grading from reviewing pathologist (Imaging Cohort, n = 250 participants, two-sided log-rank test, χ2 = 2.28, d.f. = 3, P = 0.59). (C) Gleason grading from automated classifier (Imaging Cohort, n = 250 participants, two-sided log-rank test, χ2 = 5.83, d.f. = 3, P = 0.12). (D) Gleason Morisita index, split by median. Only Gleason Morisita index shows a significant difference in time to metastasis (Imaging Cohort, n = 250 participants, two-sided log-rank test, χ2 = 5.17, d.f. = 1, P = 0.023).
