Extended Data Fig. 2: Differential protein analysis by Olink in patient subgroups in the main study cohort.
Volcano plot with the differential expressed proteins at baseline (TP0) and at the AE onset (in patients with AEs) or at the second to fifth infusion (in patients without AEs) (TP1) in patients with multiple and single AEs (a), severe and non-severe AEs (b) and according to treatment response in the main study cohort (n = 73) (c). Significant difference was determined by two-sided Wilcoxon rank sum test and p-values were adjusted by the Benjamini-Hochberg method. Linear mixed effects regression analysis of the 11 significant proteins for the two time points (TP0 and TP1) according to treatment response, in n = 36 responders and n = 37 non-responders. Data represented by estimated marginal means with 95% confidence intervals. P-values are adjusted using the tukey method (d). The y axis represents the Olink assay value (NPX).
