Fig. 7: Spatial transcriptomic analysis of lichenoid skin rash (n = 6) and immune-related colitis samples (n = 4). | Nature Cancer

Fig. 7: Spatial transcriptomic analysis of lichenoid skin rash (n = 6) and immune-related colitis samples (n = 4).

From: A targetable type III immune response with increase of IL-17A expressing CD4+ T cells is associated with immunotherapy-induced toxicity in melanoma

Fig. 7

a, UMAP plot with overview of the main cell types of the transcriptomes in the analysis of normal (n = 2) and inflamed intestine (n = 4), as well as normal (n = 2) and inflamed skin tissue (n = 6). b, Heatmap of the identified clusters and their marker gene expression. c, Dot plot with gene cell markers, including B cells and T cells (CD19 and CD8A, respectively), macrophages (CD68), keratinocytes (KRT10), epithelial cells (PIGR), fibroblasts (COL1A1), myofibroblasts (MYH11) and apoptotic cells (MT-ND5). d, Proportion analysis of the identified transcriptomic subpopulations in inflamed and normal tissue.

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