Fig. 8: Spatial transcriptomic analysis confirms a cytokine transcript of type I and III immune responses in inflamed tissue. | Nature Cancer

Fig. 8: Spatial transcriptomic analysis confirms a cytokine transcript of type I and III immune responses in inflamed tissue.

From: A targetable type III immune response with increase of IL-17A expressing CD4+ T cells is associated with immunotherapy-induced toxicity in melanoma

Fig. 8

a–p, Representative spatial transcriptomic sections for normal skin (n = 2) (a,e,i,m), lichenoid skin rash (n = 6) (b,f,j,n), normal colon (n = 2) (c,g,k,o) and immune-related colitis samples (n = 4) (d,h,l,p) with the major identified cell types and enrichment scores of signaling pathways of type I and type III immunity. q–s, Wilcoxon rank sum test analysis for the pathway enrichment scores of type I and III cytokine transcripts for the IL-17 signaling pathway (q), IFNγ signaling pathway (r) and IL-6 signaling pathway (s); each dot represents one spot. The statistical test used was two-sided and P values were adjusted by the Benjamini–Hochberg method.

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