Fig. 6: Histopathology analysis of heart tissue and ECG analysis from dogs repeatedly treated with BRD-810.
a, Beagle dogs were intravenously infused with BRD-810 for 4 h once weekly for 4 weeks before heart tissue was prepared. One representative picture is shown per group (n = 6 beagle dogs per group; three female and three male). b–f, ECG parameters (b–e) and heart rate (f) of beagle dogs before treatment (day −21), at the start of treatment (day 1, within 10 min of ceasing dosing) and after the fourth dose (day 22, within 10 min of ceasing dosing). Data are shown as the mean and s.d. (n = 3 beagle dogs per group and gender).
