Fig. 2: Differentially abundant molecules per -omic.
Top, histograms of the number of differentially abundant molecules per -omic analysis and contrast (M–B, M–D and B–D) separated by upregulated (red) and downregulated (blue) directionality (for example, red or upregulated in M–D indicates increasing abundance from mucosa to dysplastic polyp). Differential abundance was defined by an FC of ±15% and FDR of 5% for the transcriptome, an FC of ±15% and FDR of 1% for the proteome and a P value of 5% for the lipidome and metabolome. Bottom, Venn diagrams show the degree of differentially abundant molecules shared between the contrasts regardless of directionality for each single -omic. The absence of a bar (histogram) or circle (Venn diagram) means that no significant analytes were identified. The statistical tests used were two-sided Wald tests for the transcriptomic, lipidomic and metabolomic data and one-sided F-tests for the proteomic data.
