Table 1 Demographic and clinical characteristics of the patients

From: Developmental mosaicism underlying EGFR-mutant lung cancer presenting with multiple primary tumors

Patient

Age decade (gender)a

Smoking

Genetic ancestry

Stage

No. of tumors

Contralateral/Multilobar

Classification

III-1

50s (M)

Moderate

European

0

>13

Y/Y

Germline

III-4

60s (F)

Never

European

0

10

Y/Y

Germline

1

60s (F)

Former

European

IA

4

N/Y

Independentc

2

80s (M)

Former

European

IA

3b

N/N

Metastatic

3

50s (F)

Never

African

IA

>3

N/Y

Metastatic

4

50s (F)

Former

Asian

IA

>5

Y/Y

Germline

5

50s (F)

Never

African

IA

5

Y/Y

Germline

6

70s (F)

Former

European

IIB

4

N/N

Germlinec

7

70s (F)

Never

European

IB

2

N/Y

Mosaic

8

80s (F)

Former

European

IA

4

Y/Y

Mosaic

9

60s (F)

Never

European

I

4

Y/Y

Mosaic

10

70s (F)

Former

European

IA

4

Y/Y

Mosaic

  1. aSelf-reported gender.
  2. bAdditional tumors observed on pathological assessment.
  3. cSolely inferred from WES.
  4. Clinical characteristics of two patients from a familial lung cancer pedigree (III-1 and III-4) and ten patients with sporadic multiple primary lung cancers. The stage refers to the clinical impression at the time of surgical resection following the International Association of Small Cell Lung Cancer, 8th edn staging guidelines. The number of tumors corresponds to those observed on CT scans throughout the patient’s lifetime. F, Female; M, Male; N, No; Y, Yes.
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