Extended Data Fig. 5: Variant Allele Frequency distribution of mutant clones. | Nature Cancer

Extended Data Fig. 5: Variant Allele Frequency distribution of mutant clones.

From: Recapitulating the adenoma–carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids

Extended Data Fig. 5

Graphs show Variant Allele Frequency (VAF) distribution of somatic mutations per organoid clone (MLH1KO-1-WR-1-N, MLH1KO-1-WR-1+Nu, and MLH1KO-1-WR-2-N) in WES. A VAF-filtering threshold of 0.3 (dotted line) is applied to discard mutations that are introduced after the single-cell sort.

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